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Further, 21 cirrhotic patients without CSPH, 11 patients with chronic liver disease without liver fibrosis or cirrhosis and eight healthy controls were included. Diagnosis of liver cirrhosis was based on distinct sonographic, clinical and laboratory findings. In patients with CSPH, the presence of ascites was confirmed by sonography and the presence of clinically relevant varices according to the Baveno VI consensus definition medium or large varices requiring treatment by non-selective betablockers or endoscopic band ligation was assessed by endoscopy 8.

In cirrhotic patients without CSPH, the absence of varices and ascites was verified by means of endoscopy and sonography and the medical records were reviewed to exclude a history of varices or ascites. Apart from chronic liver disease, patients had no other severe cardiovascular, respiratory, renal or metabolic conditions. In 13 patients with cirrhosis, additional blood samples were obtained between one and 12 months after implantation of a transjugular intrahepatic portosystemic shunt TIPS to study the effects of portal decompression.

Sample preparation and conduction of the assay were performed according to the manufacturer's specifications. Patients' Consent and Ethics Approval All patients gave written informed consent to their participation. The study was approved by the local ethics committee of the University of Freiburg, Germany, no. Statistical Analyses The study was a comprehensive analysis of plasma cGMP levels of patients in different stages of chronic liver disease and portal hypertension.

Categorical variables are expressed as absolute and relative frequencies, continuous variables as median with interquartile range. In the absence of a Gaussian distribution of the data, differences between patient groups were assessed by Chi square tests for categorical variables and by Mann Whitney U, Wilcoxon rank sum or Kruskal Wallis tests, as applicable, for continuous variables. Predictors of CSPH were evaluated by fitting uni- and multivariable logistic regression models.

Demographic data, etiology of liver disease and the MELD score as measure of liver function were included in the models. Further, the Lok index and the aspartate-aminotransferase to platelet ratio index APRI as fibrosis scores were included, as they showed good performance in the detection of CSPH previously 9. Email A. Lee Graham lgraham bizpress. About Fort Worth employees found themselves out of work in and and John Ashour saw an opportunity.

So the longtime engineer hired several of those displaced colleagues for InterConnect, which he started in to repair harnesses and panel assemblies, provide engineering design and complete aircraft wire removal and replacement. Twenty years later, the team remains intact. And what started with four ambitious individuals now totals employees. They work in three buildings along West Vickery Boulevard. The firm owns two of the structures and rents the third for wire storage.

It also has more than 80, square feet of aircraft hangar space at Fort Worth Meacham Airport that is used for rewiring fixed or rotor wing aircraft, as well as making other aircraft modifications.

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